Migraine & Headache

Headache research has produced some of the most useful new treatments of recent years, and there is plenty still to learn. Studies here look at stopping attacks and at having fewer of them.

A young woman with her eyes closed, resting her forehead against her hand
  • Migraine
  • Chronic migraine
  • Cluster headache
  • Tension headache
  • Menstrual migraine

What studies here look at

Studies of attack treatments ask you to take the study medicine when a migraine begins, then record how you feel at set times over the next day. Prevention studies are longer: a tablet, an injection or a device used regularly, with a diary to count headache days before and during treatment.

Some research looks at what sets attacks off, such as sleep, hormones and stress, and tests whether changing them helps. Cluster headache studies often need volunteers during a bout, so timing can matter.

Who studies often look for

  • Adults with migraine attacks on several days each month

  • People who have headaches on more days than not

  • People whose migraines follow their monthly cycle

  • Adults with cluster headaches, in or between bouts

Each study sets its own requirements. Read this as the people who tend to be asked, not as a checklist.

What taking part might involve

Four things studies in this area often ask of the people who take part.

  • A headache diary

    A few taps on your phone each day, including the days with no headache at all.

  • A run-in month

    Often a month of diary keeping before any study treatment begins.

  • Treating an attack

    Taking the study medicine at the start of an attack, then rating your symptoms.

  • Check-in calls

    Short calls between visits to ask how things are going.

Questions for the study team

Take these to your first call, and note the answers.

  • What can I take if the study medicine does not stop an attack?
  • Will I need to stop the medicine I use to prevent migraines now?
  • How many attacks do I need to record, and over what period?

Hear about studies in this area

Sign up with Migraine & Headache as your area and your ZIP code, and we will text you when a study near you lines up.

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See what is recruiting today

ClinicalTrials.gov is the public U.S. list of studies. This search shows recruiting studies for migraine.

Open the registry search